Medium and low pressure polypropylene columns are resistant to acid and alkali, as well as most organic solutions such as alcohol solutions, acetone and acetonitrile. Resins or fillers can be regenerated inside the column, and mirrors can be installed according to requirements. Adopting a unique distribution device to ensure uniform penetration of the material and liquid. The working flow rate can be adjusted according to the actual situation, using sanitary grade quick installation movable joint pipelines, which can be completely cleaned online. The sieve plate or liquid flow distributor can be replaced according to the number of filler mesh. The filling material can be manually operated or automatically filled (with a feeding device).